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Forskolin, 10 MG

Price$ 87.65
  • SKU: F-1026-10MG
  • Pack Size: 10 MG
Quantity
-
+

66575-29-9

410.5 Da

C22H34O7

May be dissolved in DMSO (160 mg/mL) or Ethanol (50mg/mL)

+4°C


Description

Forskolin is a cell-permeable labdane diterpene derived from Coleus Forskohlii which directly stimulates adenylate cyclase (AC). This unique diterpene increases in levels of intracellular cyclic AMP (cAMP) from ATP in various eukaryotic cells by activating AC. cAMP is a second messenger mediating a variety of signaling pathways and is related to lipolysis via thermogenesis. It is reported that forskolin induces CYP3A gene expression in primary hepatocytes by functioning as agonists of the pregnane X receptor (PXR). Protein kinase A (PKA) signal transduction pathway activated by cAMP enhances CYP3A gene expression induced by PXR.

This compound is a potent inhibitor of platelet aggregation and proven for antitumor effects. cAMP signaling related to forskolin is relevant to the effects in induction of mesenchymal-to-epithelial transition, inhibition of cell proliferation and metastasis. In addition, it helps sensitivity to antitumor drugs enhanced in cancer cells.

The natural compound is also inotropic and has been used for hypertension and respiratory disorders as well.

 

Applications

• Study for signaling pathway

• Study for antitumor drug

• Inotropic agent 

 

Additional Reading

• AGS Blog: Forskolin for Weight Loss - A Natural Remedy!

 

References

• “Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?”

• “Forskolin: a unique diterpene activator of cyclic AMP-generating systems”

• “Forskolin: A potential antimetastatic agent”

• “The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?”

• “Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway"

• “A New Potential Weapon for Fighting Obesity: Forskolin—the Active Diterpene in Coleus”

  

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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