4-Bromocalcimycin; 4-bromo-Calcium Ionophore A23187; 6-bromo-5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)- 3,9,11-trimethyl -8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol -2- yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4- benzoxazolecarboxylic acid
76455-48-6
602.5
C29H36BrN3O6
DMF, DMSO
-20°C
4-Bromo-A23187 is a halogenated analog and divalent ionophore of A23187. Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes.
Studies conducted in quin-2-loaded thymic lymphocytes of rat, 4-Bromo-A23187 has shown to saturate Ca2+ sites. This activity of 4-Bromo-A23187 has been suggested to be identical to ionomycin. Affinity towards Zn2+ and Mn2+ transportation, has been used for investigating cell regulation by Zn2+ and Mn2+.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
