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MCC-950, 25 MG

Price$ 275.00
  • SKU: M-3339-25MG
  • Pack Size: 25 MG
Quantity
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N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CRID3; CP-456773 sodium salt

256373-96-3

426.5

C20H23N2O5S • Na

Water, DMSO

-20°C


MCC-950 was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-1. Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes. Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations. Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model). Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome. A valuable new tool for exploring the pathophysiology of NLRP3.

 



Research or further manufacturing use only, not for food or drug use.

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