LY317615
170364-57-5
515.6
C32H29N5O2
DMF, DMSO
-20°C
Enzastaurin is a potent and selective inhibitor of PKC with antiproliferative activity (IC= ~6 nM). Binding to the ATP-binding site, enzastaurin selectively inhibits Protein kinase & protein kinase C beta.
Enzastaurin suprpresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density, and prevents VEGF secretion from human tumor cell xenografts in nude mice. Prolonged courses of Enz increase chemotherapy or radiation tumor growth delay of glioma, breast, and small cell lung cancer xenografts.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
