BAY-h-5955; D-1-Deoxynojirimycin; 1-DNJ; 1-dNM; Moranoline
19130-96-2
163.2
C6H13NO4
DMSO, PBS (pH 7.2)
-20°C
1-deoxynojirimycin (DNJ), also called duvoglustat or moranolin. 1-deoxynojirimycin derived from Mulberry leaves, is a potent inhibitor of intestinal α-glycosidases, which acts as an antihyperglycemic agent by slowing the rate of carbohydrate degradation to monosaccharides. Deoxynojirimycin inhibits α-glucosidase I and II.
Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. May be used to produce an affinity ligand for purifying glucosidase 1. Deoxynojirimycin was used to inhibit ER glucosidases I and II allowing for the discovery of a second mechanism for deglucosylation of N-linked oligosaccharides in PhaR1.7, a mouse lymphoma cell line.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
