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Santacruzamate A, 5 MG

Price$ 80.00
  • SKU: S-4006-5MG
  • Pack Size: 5 MG
Quantity
-
+

N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

1477949-42-0

278.4

C15H22N2O3

DMSO, Ethanol

-20°C


Santacruzamate A is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively). Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors. Potential therapeutic agent for breast cancer. Attenuates A fragment (Ab25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance4. Ameliorates Alzheimer’s disease-like pathology in mouse models.

 



Research or further manufacturing use only, not for food or drug use.

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