ATM Kinase Inhibitor
587871-26-9
395.5
C21H17NO3S2
DMF, DMSO, Ethanol
-20°C
Ku-55933 is a potent, selective and ATP-competitive inhibitor of ATM Kinase (K = 2.2 nM; IC= 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC= 2500, 9300, 16600, 100000 and 100000 nM, respectively). KU-55933 inhibits cancer cell proliferation by inducing G(1) cell-cycle arrest. Sensitizes cells to ionizing radiations and chemotherapeutics. Induces apoptosis in breast and prostate cancer cell lines.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
