3-[4-(4-morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol
371935-74-9
348.4
C19H16N4O3
DMF, DMSO
-20°C
PI-103 is a cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110), and mTOR. The ICvalues are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110, mTORC1, PI3-KC2, p110, mTORC2, p110, and p110, respectively. Inhibits growth of human tumor xenografts in mice in vivo.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.