133812-16-5
245.3
C14H15NO3
DMSO, Methanol
-20°C
Locostatin is a cell-permeable potent inhibitor of Raf kinase inhibitor protein (RKIP) with Raf1 kinase interaction.
Locostatin blocks eukaryotic cell migration (IC₅₀ = 14 µM for inhibition of wound closure in MDCK cell monolayers) and decreases formation of lamellipodial protrusions at wound margins.
Inhibits early development in frog embryos and tissue dynamics in embryonic explants. No antibacterial activity displayed.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
