2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
304896-28-4
434.3
C23H13Cl2N3O2
DMF, DMSO
-20°C
AGK2 is a potent inhibitor of sirtuin 2 (SIRT2) (IC= 3.5 M). AGK2 is 15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued synuclein toxicity and modified inclusion morphology in a cellular model of Parkinsons disease.
0.1 lbs
Substance Name:3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; 2',7-Dihydroxy-3,4-benzocoumarin
CAS Number:1143-70-0
Substance Name:5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Substance Name:Changchuanmycin; FK-520; FR900520; Immunomycin; L 683590
CAS Number:104987-12-4
Substance Name:3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; 2',7-Dihydroxy-3,4-benzocoumarin
CAS Number:1143-70-0
Substance Name:5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid