NSC 112546; SIRT1 Inhibitor II; SIRT2 Inhibitor VI
14513-15-6
360.4
C21H16N2O2S
DMF, DMSO
-20°C
Cambinol is an inhibitor of NAD-dependent deacetylase activity of human SIRT1 (IC50 = 56 µM) and SIRT2(IC50 = 59 µM). Acts as an antitumor agent. Treatment of BCL6-expressing Burkitt lymphoma cells with Cambinol induces apoptosis accompanied by hyperacetylation of BCL6 and p53.
0.1 lbs
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