10-[(Dimethylamino)methyl]-4S-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, HCl; NSC 609669; SKF-104864A
119413-54-6
C23H23N3O5 • HCl
DMSO, Water
-20°C
Water-soluble and orally active analog of camptothecin, a DNA topoisomerase I inhibitor. Inhibits topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells, IC50s = 13 and 2 nM respectively. Downregulates B-Myb and MycN expression in neuroblastoma cells. A clinically useful anticancer agent.
Research or further manufacturing use only, not for food or drug use.
