(3Z)-5-bromo-1,3-dihydro-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-2H-indol-2-one
288144-20-7
343.2
C17H15BrN2O
DMF, DMSO
-20°C
Synonym: (Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
A membrane permeant indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-R, 4.92 M for p60c-src, and 13.3 M for FGF-R1]. The inhibition is suggested to be competitive with respect to ATP. Also inhibits VEGF-induced (IC = 100 nM) and PDGF-induced (IC = 2.01 M)cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC 100 M).
0.1 lbs
Research or further manufacturing use only, not for food or drug use.