Aprotinin, bovine lung

SKU
A-1420
  • CAS:9087-70-1
  • Formula:C284H432N84O79S7
  • MW:6511.5 Da
  • Appearance:White to off-white crystalline powder
  • Purity:≥95%

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Starting at $45.56

Product Name Qty
Aprotinin, bovine lung
100 mg
$136.69
Aprotinin, bovine lung
25 mg
$45.56

Description

Aprotinin is a natural serine protease inhibitor from bovine lung tissue. It inhibits trypsin, chymotrypsin, Factor XII, plasmin and kallikrein which are related to fibrinolysis. Some proteases like Factor Xa, thrombin and pepsin are not affected by aprotinin. It is heat- and acid-stable, however it dissociates at pH >10 or <3 from most aprotinin-proteases. Effective concentration is equimolar with protease. It is also used to preserve platelet number and organs for transplantation and function for transfusion. 


Applications

• Protein purification

• Used to preserve biological fluids, cells, and tissues from proteolytic damage


References

• "Aprotinin: A Review of its Pharmacology and Therapeutic Efficacy in Reducing Blood Loss Associated with Cardiac Surgery"

More Information
Alternate Name/Synonyms
Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor
SKU
A-1420
CAS #
9087-70-1
Chemical Name
4-[[1-[[29a,62a,69,84-tetrakis(4-aminobutyl)-35a,75,78-tris(2-amino-2-oxoethyl)-14a-(3-amino-3-oxopropyl)-8a,41a,72-tribenzyl-50a,53a-di(butan-2-yl)-47a,48,56a,81,90-pentakis(3-carbamimidamidopropyl)-31,60-bis(2-carboxyethyl)-42-[[2-[[2-(1-carboxyethylami
Chemical Formula
C284H432N84O79S7
Molecular Weight
6511.5 Da
Appearance
White to off-white crystalline powder
Purity
≥95%
Solubility
Clear, colorless solution. 1% freely soluble in water.
Storage Temp
+4°C
THERAPEUTIC AREA
Not Available
USE
Small amounts of aprotinin can be added to tubes of drawn blood to enable laboratory measurement of certain rapidly degraded proteins such as glucagon. In cell biology aprotinin is used as an enzyme inhibitor to prevent protein degradation during lysis or homogenization of cells and tissues.
MDL NUMBER
MFCD00130541
CHEMACX
X1009358-8
INCHI
InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3
Peptide sequence
H-ARG-PRO-ASP-PHE-CYS-LEU-GLU-PRO-PRO-TYR-THR-GLY-PRO-CYS-LYS-ALA-ARG-ILE-ILE-ARG-TYR-PHE-TYR-ASN-ALA-LYS-ALA-GLY-LEU-CYS-GLN-THR-PHE-VAL-TYR-GLY-GLY-CYS-ARG-ALA-LYS-ARG-ASN-ASN-PHE-LYS-SER-ALA-GLU-ASP-CYS-MET-ARG-THR-CYS-GLY-GLY-ALA-OH ACETATE 
RTECS
YN5080000
Handling
Hygroscopic, keep tightly sealed. Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation.
Citations
FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions Vivian W. Tang and William M. Brieher J. Cell Biol., Dec 2013; 203: 815 - 833.
Citations_Hyperlink
http://jcb.rupress.org/content/203/5/815.full.pdf+html
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Hygroscopic, keep tightly sealed. Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation.
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