Sodium dodecyl sulfate (SDS or NaDS), sodiumlaurilsulfate or sodium laurel sulfate (SLS) is an organic compound with the formula CH3(CH2)11OSO3Na. It is an anionic surfactant used in many cleaning and hygiene products.

What is SDS detergent?
Sodium dodecyl sulfate is also known as SDS detergent and sodium lauryl sulfate (SLS). This detergent is an organic compound with the chemical formula C12H25NaSO4. It is an anionic surfactant used in a variety of cleaning products. The salt is of an organo-sulfate consisting of a 12-carbon tail attached to a sulfate group, giving the material the amphiphilic properties required of a detergent. Being derived from inexpensive coconut and palm oils, it is a common component of many domestic cleaning and hygiene products.How is Sodium Dodecyl Sulfate produced?
SDS is synthesized by treating lauryl alcohol with sulfur trioxide gas, oleum, or chlorosulfuric acid to produce hydrogen lauryl sulfate.The trioxide gas method is the typical method used at the industrial level. The resulting product is then neutralized through the addition of sodium hydroxide or sodium carbonate.
SDS Detergent in the Laboratory
SDS can be used to aid in lysing cells during DNA extraction and for unraveling proteins in SDS-PAGE electrophoresis. The compound disrupts the non-covalent bonds in the proteins, causing them to denature and lose their native shape. The new negative charge is significantly greater than the original charge of the protein and the electrostatic repulsion that is created by the binding of sodium dodecyl sulfate causes the proteins to unfold into a rod-like shape. This change in conformation eliminates differences in shape as a factor for the separation of proteins in the gel.
Medical Applications of SDS Detergent
In medicine the detergent is used rectally as a laxative in enemas and as an excipient on some dissolvable aspirins and other fiber therapy caplets. Sodium Dodecyl Sulfate has also been proposed as a potential topical microbicide for intravaginal use to inhibit and potentially prevent infectino by viruses, including Herpes simplex, HIV, and Semliki Forest virus.Additional Reading
- Tips for Selecting Biological Detergents
- Detergents: Important Tools for Membrane Protein Purification
- Sulfobetaines, Zwitterionic Biodetergents in Diagnostics
Biological Detergent E-Brochure: Download Now
Sources
- Bales, Barney L., et al. "Precision relative aggregation number determinations of SDS micelles using a spin probe. A model of micelle surface hydration." The Journal of Physical Chemistry B 102.50 (1998): 10347-10358.