Mycophenolic Acid (MPA)

SKU
M-1036
  • CAS:24280-93-1
  • Formula:C17H20O6
  • MW:320.3 Da
  • Appearance:White powder
  • Purity: ≥ 98%

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Product Name Qty
Mycophenolic Acid
250 mg
$117.30
Mycophenolic Acid
500 mg
$194.78
Mycophenolic Acid
1 g
$390.85

Description:

Immunosuppressive agent Mycophenolic acid (MPA) inhibits inosine monophosphate dehydrogenase. It selectively inhibits lymphocyte proliferation by blocking the enzyme, inosine monophosphate dehydrogenase, part of in the guanosine monophosphate pathway. It has been tested extensively in renal transplant patients and has been shown to be effective in reducing the incidence of acute graft rejection. 

Applications:

• Used in the de novo synthesis of purine nucleotides
• Used in clinical settings as a chemotherapeutic or immunosuppressant agent
• Used for transfected animal cells expressing the E. coli gene for xanthine-guanine phosphoribosyl transferase

More Information
Alternate Name/Synonyms
MPA; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid; NSC 129185; Myfortic; Melbex
SKU
M-1036
CAS #
24280-93-1
Chemical Name
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
Chemical Formula
C17H20O6
Molecular Weight
320.3 Da
Appearance
White powder
Purity
≥ 98%
Solubility
Clear Colorless Solution at 50 mg/mL DMSO; or 30 mg/mL Ethanol
Melting Point
145-146ºC
Storage Temp
4°C
THERAPEUTIC AREA
Autoimmune Diseases
USE
Mycophenolic Acid is an immunosuppressant small molecule isolated as a fermentation product from several Penicillium species. Mycophenolic Acid functions as a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP in the cell and interruption of the de novo synthesis of purines necessary for lymphocyte proliferation. This powerful immunosuppressant property has been exploited in studies on organ transplant survival, rhuematoid arthritis, and psoriasis. Derivitization of Mycophenolic Acid to the morpholinoethyl ester, known as Mycophenolate mofetil (sc-200971), presents a greater bioavailability for the active compound.
Merck Index
13.6352.2001
MDL NUMBER
MFCD00036814
CHEMACX
X1002405-4
INCHI
InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)
SMILES
Cc1c2c(c(c(c1OC)CC=C(C)CCC(=O)O)O)C(=O)OC2
RTECS
MP8050000
UN #'S
UN 3077
PACKING GROUP
III
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
msds 1
/media/upload/pdf/M-1036, Mycophenolic Acid, SDS, diamond format.pdf
Certificate of Analysis 1
/media/upload/pdf/M-1036, J1121.pdf
Certificate of Analysis 2
/media/upload/pdf/M-1036, G1307.pdf
Certificate of Analysis 3
/media/upload/pdf/M-1036, F1225.pdf
GHS PICTOGRAMS
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
UN #'S UN 3077
Packing Group III
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