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17-DMAG, 1 MG

Price$ 60.30
  • SKU: A-1298-1MG
  • Pack Size: 1 MG
Quantity
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+

467214-20-6

616.8

C32H48N4O8

Soluble in DMSO, Methanol, Ethanol

-20°C


Description

17-DMAG binds to Hsp90 and alters its function. A water soluble cell-permeable analog of Geldanamycin and 17-AAG, 17-DMAG binds to the APTase site of human Hsp90 with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor.Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-alpha increase, and caspase-3 activation. HSP90 inhibits, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(DMAG) to increase the radiosensitivity of tumor cells in vitro. HSP90 inhibitor, 17-DMAG, enhances radiosensitivity of human cancer cells.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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