50-35-1
258.2
C13H10N2O4
May be dissolved in DMSO
Room Temperature
Description
Thalidomide binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A inhibiting ligase activity. Inhibits TNFα synthesis and FGF-induced angiogenesis. Cell permeable.
Caution: Teratogenic. Pregnant women should avoid using this compound.
References
• Identification of a Primary Target of Thalidomide Teratogenicity
• Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency
• Thalidomide is an inhibitor of angiogenesis
Not for human therapeutic use or for medicinal purposes. For research applications only.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
