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Nocodazole, 5 MG

Price$ 40.00
  • SKU: N-1177-5MG
  • Pack Size: 5 MG
Quantity
-
+

31430-18-9

301.3

C14H11N3O3S

Soluble in DMSO (10mg/mL), or Dimethyl Formamide. Almost insoluble in water.

Room Temperature


Description

Nocodazole is a synthetic and reversible microtubule inhibitor. It inhibits microtubule polymerization and makes the arrests cells at the G2/M phase. It binds to beta-tubulin and suppresses mitotic spindles

Due to its anti-mitotic properties, it is used to induce apoptosis and for production of mitotic mammalian cells. Arrested cell cycles by the drug can return to normal cell cycles when it is removed.

It has been reported certain concentrations of nocodazole increase p53 and p53-DNA binding and accumulate p21 mRNA in NIH-3T3 fibroblasts.

 

Applications

• Antimitotic agent

• Apoptosis inducer

 

References

“Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor Nocodazole: Nocodazole accumulated mitotic cells”

“Effects of nocodazole on structures of calf brain tubulin”

“Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis”

“Microtubule-active Drugs Taxol, Vinblastine, and Nocodazole Increase the Levels of Transcriptionally Active p53”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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