88321-09-09
342.433
C17H30N2O5
Soluble in EtOH (10 mg/mL) and DMSO (20 mg/mL)
-20°C
Description
An irreversible, highly selective cysteine protease inhibitor and cell permeable analog of E-64D. Specifically E-64D is an irreversible cathepsin L and B inhibitor.
E-64d has played an imporant role in studies of the Ebola virus (EBOV). E-64d has been shown to lead to the accumulation of CTFs and AICD with no change ingamma and beta secretase activities. Additionally, utilizing E-64d has shown results in accumulation of autophagic bodies inside vacuoles in Arabidopsis root cells.
References
• http://mbio.asm.org/content/7/1/e01857-15.full.pdf+html
Not for human therapeutic use or for medicinal purposes. For research applications only.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
