(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N- [[[(1S)-1- carboxy-3-methylbutyl]amino]carbonyl]glycylN1-[(1S)-1-methyl -2-ox
51798-45-9
512.56
C21H36N8O7
Water
-20°C
Elastatinal is a tetrapeptide derivative with an aldehyde group which is essential for inhibitory activity such as pancreatic elastase. It is a much stronger inhibitor of elastase from pancreas than from leucocytes because it’s isolated from Actinomycetes.
Elastatinal is a highly specific inhibitor of elastase-like serine proteases. Elastatinal can also be used as an inhibitor for thermitase, a thermostable serine protease from Thermoactinomyces vulgaris, and for macroglobulin-protease complexes.
Elastatinal inhibits the proteolytic activity of poliovirus and rhinovirus 2A proteinases in vitro. Additionally, it has no effect on DNA repair and UV-induced sister chromatid exchanges, and inhibits the cleavages found at Ala-Ala bonds in peptides that represent the capsid/nucleocapsid site. Elastatinal is an irreversible inhibitor of neutrophil and rat microglia elastase.
Applications:
- Used as a microbial product inhibitor for elastase
- Ability to inhibit poliovirus and rhinovirus 2A proteinases in vitro
- Ability to reduce rate of degradation of endostain
- Used to effectively inhibit phenylmethylsulfonyl fluoride
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
